For incoming tourists.
Distillery District - has NO CARS, some nice shops and balzac's coffee, but expensive and closes early and always full of tourists
St Lawrence Market
Queen Street West though you have to go pretty far west these days for the edgy artistic stuff. Still the Queen Mother's an old favourite and Ghandi Roti is amazing.
Contemporary Art Museum (Queen West)
Art Gallery of Ontario (AGO)
College Street including Croft Street
Bloor Street West
Bata Shoe Museum is actually pretty neat
Yonge Street (South of Bloor)
Danforth & Broadview park for a great city view on a clear night
Yonge Street (North of Bloor) is cute, visit the 'seven thieves' shops for expensive food.